The CTX M Conundrum Dissemination of Plasmids and


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Dissemination and Characterization of Plasmids Carrying ....

The co-dissemination of oqxAB-bla CTX-M genes in E. coli isolates from food-producing animals is mediated mainly by similar F33:A-: B- and HI2 plasmids. This is the first report of the co-existence of oqxAB, bla CTX-M, and floR on the same plasmids in E. coli.

The CTX-M Conundrum: Dissemination of Plasmids and ....

6 Such global and rapid dissemination of CTX-M-type ESBL has primarily been attributed to their presence on plasmids. 3,7 CTX-M-type enzymes were first identified in clinical Enterobacteriaceae ...

Dissemination of IncF-type plasmids in multiresistant CTX ....

During the past decade, CTX-M enzymes have gradually replaced the classical TEM and SHV-type ESBLs in many countries . Rapid international spread of CTX-M-15 has been associated with global dissemination of Escherichia coli clones, such as sequence type 131 (ST131) harbouring bla CTX-M-15 on incompatibility group (Inc) FII conjugative plasmids .

Molecular Characterization of CTX-M β-Lactamase and ....

The spread of bla CTX-M genes was attributed to both clonal expansion and horizontal dissemination. Our data suggest that a combination of multiple addiction systems in plasmids carrying bla CTX-M genes could contribute to their maintenance in the host cells.

Escherichia coli and Klebsiella pneumoniae Producing CTX-M ....

Escherichia coli and Klebsiella pneumoniae Producing CTX-M Cephalosporinase from Swine Finishing Barns and Their Association with Antimicrobial Use ... 2 isolates from the same barn represented a single clonal strain carrying bla CTX-M-15 on IncF plasmids. ... The CTX-M conundrum: dissemination of plasmids and Escherichia coli clones.

1. Introduction - downloads.hindawi.c...

The CTX-M enzymes have been the most predominant among Enterobacteriaceae [36]. CTX-M group 1 is represented by b l a CTX-M-1, b l a C T X-M-3, and b l a CTX-M-15, with b l a CTX-M-1 and b l a CTX-M-15 being associated with plasmids belonging to incompatibility groups IncI1, IncFII, and IncN [37], most of which were detected in this study.

(PDF) Dissemination of IncF-type plasmids in ....

Dissemination of IncF-type plasmids in multiresistant CTX-M-15-producing Enterobacteriaceae isolates from surgical-site infections in Bangui, Central African Republic

The CTX-M Conundrum: Dissemination of Plasmids and Escherichia coli Clon...

Multireplicon FII plasmids are shown to carry the most widely distributed bla (CTX-M-15) across continents, paving the way for bla (CTX-M-15) into different genetic lineages of E. coli. Dissemination of virulent clones ST131-O25:H4-B2 and ST405-O102:H6-D is now being described worldwide.

Dissemination of pHK01-like incompatibility group IncFII ....

Read "Dissemination of pHK01-like incompatibility group IncFII plasmids encoding CTX-M-14 in Escherichia coli from human and animal sources, Veterinary Microbiology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

(PDF) Replicon typing of plasmids carrying bla CTX−M−1 in ....

Objectives: The aim of this work was to determine the plasmid replicon profiles of a collection of bla CTX-positive enterobacterial strains. The isolates originated −M−1 from chicken in the production pyramid, healthy food-producing animals at

Dissemination of pHK01-like incompatibility group IncFII ....

Dissemination of pHK01-like incompatibility group IncFII plasmids encoding CTX-M-14 in ... In conclusion, this study highlights the importance of the IncFII group, pHK01-like plasmids in the dissemination of CTX-M-14 among isolates from diverse sources. ... A. SundsfjordThe CTX-M conundrum: dissemination of plasmids and Escherichia coli ...

The CTX-M Conundrum: Dissemination of Plasmids and ....

The mobilization of bla CTX-M genes from their original chromosomal position in various Kluyvera species has been facilitated by mobile genetic elements such as ISEcp1 or ISCR1. Molecular epidemiological studies have revealed a thriving linkage of bla CTX-M genes to conjugative plasmids and

Dissemination of pHK01-like incompatibility group IncFII ....

Hence, the dissemination of CTX-M-14 has been attributed to conjugative plasmids and other mobile genetic elements rather than clonal expansion (Naseer and Sundsfjord, 2011). In Spain, the spread of CTX-M-14 from 2000 to 2005 was largely due to pRYC105-like plasmids of the IncK incompatibility group disseminated among diverse E. coli lineages ...

Clonal diversity of CTX-M-producing, multidrug-resistant ....

The CTX-M producing isolates were genetically diverse but a large proportion (47.8 %) were included in six successful clones that are strongly associated with human diseases and CTX-M dissemination, viz. sequence type complex [STC]10/phylogroup A, STC23/phylogroup B1, STC38/phylogroup D, STC155/phylogroup B1, ST405/phylogroup D and ST131 ...

(PDF) Persistence of a pKPN3-Like CTX-M-15-Encoding ....

To characterize the CTX-M-15-encoding plasmid in a Klebsiella pneumoniae ST17 strain, responsible for an outbreak at a Norwegian neonatal intensive care unit and subsequent colonization of affected children for up to two years. To identify

Analysis of bla CTX-M-Carrying Plasmids from Escherichia ....

The bla CTX-M-1 upstream regions of plasmids pCTX168 and pCTX246 were similar, whereas the downstream regions showed structural differences. The genetic environment of the bla CTX-M-15 gene on plasmid pCTX913 differed distinctly from that of both bla CTX-M-1 genes.

CTX-M-15-producing Escherichia coli clone B2-O25b-ST131 ....

Plasmids associated with bla CTX-M in E. coli. From a total of 26 CTX-M-producing isolates, conjugation to E. coli and/or Salmonella was demonstrated only in 4. Transconjugants to E. coli and Salmonella were obtained from one ST131 strain (OV54/B).

Escherichia coli and Klebsiella pneumoniae Producing CTX-M ....

Escherichia coli and Klebsiella pneumoniae Producing CTX-M Cephalosporinase from Swine Finishing Barns and Their Association with Antimicrobial Use ... 2 isolates from the same barn represented a single clonal strain carrying bla CTX-M-15 on IncF plasmids. ... The CTX-M conundrum: dissemination of plasmids and Escherichia coli clones.

Dissemination of pHK01-like incompatibility group IncFII plasmids encoding CTX-M-14 in Escherichia coli from human and animal sourc...

Read "Dissemination of pHK01-like incompatibility group IncFII plasmids encoding CTX-M-14 in Escherichia coli from human and animal sources, Veterinary Microbiology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

The CTX-M Conundrum: Dissemination of Plasmids and ....

The ongoing global spread and increased prevalence of CTX-M-type extended-spectrum β-lactamases in Enterobacteriaceae is of great concern. The successful distribution of CTX-M enzymes mainly involves Escherichia coli causing systemic as well as urinary tract infections in patients worldwide. CTX-M expression is often associated with coresistance that critically reduces treatments options.

CTX-M Enzymes: Origin and Diffusion - CO...

The CTX-M conundrum: dissemination of plasmids and Escherichia coli clones. (2006). The CTX-M β-lactamase pandemic. (2005). The new β-lactamases. (2010). The profile of antibioticsresistance and integrons of extendedspectrum β-lactamase producing thermotolerant coliforms isolated from the Yangtze River basin in Chongqing. ...