Identity of molecules bearing murine ia alloantigenic specificities Ia 7


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Cornelia Weyand's Profile | Stanford Profil...

Cornelia Weyand is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more). The site facilitates research and collaboration in academic endeavors.

The Human la System - ScienceDire...

The chapter examines the Ia antigens from two principal perspectives: (1) as membrane components related to differentiation, and (2) as part of a genetically intricate system of molecules bearing alloantigens that have relevance to susceptibility to certain diseases.

Structural characteristics of the alloantigens determined ....

Structural characteristics of the alloantigens determined by the major histocompatibility complex of the guinea pig. ... The Ia-bearing molecules identified by anti-Ia.2,4 are glycoproteins of mol wt 58,000 daltons which are composed of two subunits of 33,000 and 25,000 daltons, respectively, linked by disulfide bonds. ...

Three Ia species with different structures and ... - CO...

Three Ia species with different structures and alloantigenic determinants in an HLA-homozygous cell line . By . ... Identity of molecules bearing murine Ia alloantigenic specificities Ia.7 and Ia.22: evidence for a single type of I-E molecule in homozygotes. ...

WO2003025119A2 - Compositions comprising immunostimulatory ....

Compositions comprising immunostimulatory oligonucleotides (CpGODN) and FcR-directed immunotherapeutics are disclosed. Also disclosed are methods of using the compositions to enhance FcR-mediated antigen presentation, ADCC, and other FcR-mediated immune responses.

The Major Histocompatibility Complex - ResearchGa...

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Structural characteristics of the alloantigens determined ....

The Ia-bearing molecules identified by anti-Ia.2,4 are glycoproteins of mol wt 58,000 daltons which are composed of two subunits of 33,000 and 25,000 daltons, respectively, linked by disulfide bonds. The Ia-bearing molecules are independent of GPLA-bearing molecules, indicating different loci determining these antigens.

US20030072762A1 - Compositions comprising ....

US20030072762A1 US10/209,070 US20907002A US2003072762A1 US 20030072762 A1 US20030072762 A1 US 20030072762A1 US 20907002 A US20907002 A US 20907002A US 2003072762 A1 US2003072762 A1 US 2003072762A1 Authority US United States Prior art keywords composition antigen cell method antibody Prior art date 2001-08-03 Legal status (The legal status is an assumption and is not a legal conclusion.

Donald C. Shreffler | Biographical Memoirs: Volume 82 ....

With S.E.Cullen, C.S.Kindle, and C.S.David. Identity of molecules bearing murine Ia alloantigenic specificities Ia.7 and Ia.22: Evidence for a single type of I-E molecule in homozygotes. Immunogenetics 11:535–47. 1982 With D.R.Karp and J.P.Atkinson. Genetic variation in glycosylation of the fourth component of murine complement. J. Biol.

JCI - Volume 92, Issue...

These adhesion molecules include: lymphocyte homing receptors involved in tissue-selective binding of lymphocytes to peripheral lymph node (L-selectin) or mucosal lymphoid tissue (LPAM-1, alpha 4 beta 7-integrin) high-endothelial venules (HEV); and HEV ligands peripheral vascular addressin (PNAd) and mucosal vascular addressin (MAdCAM-1).

Identity of molecules bearing murine ia alloantigenic ....

By S E. Cullen, D C. Shreffler, C S. Kindle, et al., Published on 01/01/80. Title. Identity of molecules bearing murine ia alloantigenic specificities ia.7 And ia.22: Evidence for a single type of i-e molecule in homozygotes.

Expression of Ia Antigens on Langerhans Cells in Mice ....

In all mammalian species so far examined, Langerhans cells or their precursors are the only epidermal cells expressing Ia antigens or their equivalents. In man, xenoantisera raised in rabbits against purified B lymphocyte cell membrane antigens were utilized to stain the Langerhans cells, by either fluorescence or immunoferritin methods. A high proportion of the indeterminate cells in the ...

The Journal of experimental medicine Journal - vivo.upenn.e...

Differentiation of Ia-reactive CD8+ murine T cells does not require Ia engagement. Implications for the role of CD4 and CD8 accessory molecules in T cell differentiation. Direct evidence for the role of COOH terminus of mouse mammary tumor virus superantigen in determining T cell receptor V beta specificity.

Human Ia molecules carrying DC1 or BR4X7 ... - SpringerLi...

Human Ia molecules carrying DC1 or BR4X7 determinants are not homologous to murine I-E molecules. Authors; Authors and affiliations ... S. E., Shreffler, D. C., Kindle, C. S., and David, C. S.: Identity of molecules bearing murine Ia alloantigenic specificities Ia. 7 and Ia. 22: Evidence for a single type of I-E molecule in ...

WikiGenes - Cd5 - CD5 antig...

Thus the thymomas could be classified into 7 groups based on the differing expressions of Ia, Ly-1, Ly-2, Ly-4, and Ly-6 specificities; all tumors were H-2+, Ly-5+, Ly-9+, and Ly-15+ . However, certain surface Ig-positive B lymphomas do express the Lyt-1 antigen .

Identity of molecules bearing murine ia alloantigenic ....

Abstract. In homozygous mice bearingI regions derived from haplotypek, only a single type of Ia molecule bearing the alloantigenic specificities Ia.7 and Ia.22 was found using techniques of sequential immune precipitation and tryptic peptide analysis.As suggested at the fourth Ir Gene Workshop (Sachs 1978), Ia.7 is considered here to be an antigenic determinant associated with I-E ...

Identity of molecules bearing murine Ia alloantigenic ....

Since the I-C subregion is not involved with the determination of these Ia molecules, and since in homozygotes there is apparently only a single type of molecule bearing both specificities Ia.7 and Ia.22, the term 'I-E/C' molecule should probably be dropped in favor of the simpler designation I-E.

(PDF) Possible Detection of HLA-DR Alloantigenic ....

Possible Detection of HLA-DR Alloantigenic Specificities in Man with Unabsorbed Rabbit Antisera

Glycoprotein Antigens of Murine Lymphocytes - ScienceDire...

This chapter discusses glycoprotein antigens of murine lymphocytes. It discusses the techniques presently utilized to identify and quantitate cell surface antigens and summarizes the biochemical data available on H-2 and Ia, the antigens of the major histocompatibility (MHC) gene complex, and on the T-cell differentiation antigens, Thy-1, Tla, and Ly-2,3.

(PDF) Beta 2-microglobulin is selectively associated with ....

Results indicate that virtually all the molecules in detergent lysates of murine lymphoid cells which can be precipitated with this antiserum have mol wts greater than 100,000 and consist of subunits of 44,000 and 12,000. ... The antiserum also reacts with antigens ceded for by the IA k subregion. ... cells with iodoaceta- mide before or during ...

Human leucocyte antigen (HLA) expression of primary ....

Human trophoblast cells express an unusual repertoire of human leucocyte antigen (HLA) molecules which has been difficult to define. Close homology between and extreme polymorphism at the classical HLA class-I (HLA-I) loci has made it difficult to generate locus-specific monoclonal antibodies (mAbs).